Chronic illnesses that come along like buses.

And health wise life is not going to get any better.

Yup, biting earlier than usual and big feckers too. Got midged at Loch Maree the other weekend. Didn't think they were midges at the time as size was between the usual and a small house fly, but bites have come up exactly like midge bites do on me.

Also got a tick off the dog the other evening.

Without a doubt Humira or biosimilar, or other biologic is far better than prednisone to be on long term.

Pred is a short term drug, get you into remission, minimise damage as fast as possible, She really should not be on pred for long as otherwise weight gain, bone density loss, thin skin and bruising easily, hypertension issues/etc can kick in.

Tingling is a side effect of pred, but also is a serious side effect of Humira. Talk to her prescribing doctor sooner rather than later.

We were in the park when an older lady asked us if we'd seen a pup/etc. So I said to Jessie lets go find the puppy. The pup had fallen off a fishing platform into the lake and was tucked under it, completely out of sight unless you went right to the edge and looked under it. Jessie wouldn't let me leave until I'd spotted it. Scooped this tiny, wet and shaking pup out and handed it to the lady who was very grateful as it was her gran-daughters dog. It was a pretty cold day so I doubt it would have survived for long.

Thanks for the update.

We had a pedigree BC from rescue who didn't eat for 3 days when we first got him. The rescue had said they couldn't get him to eat much. Our vet gave him an injection of something to stimulate his appetite which helped. We ended up giving him his food for that day and let him choose when to eat. Sometimes it would be untouched as we went to bed, but usually gone in the morning.

It's been quite a few years since he passed but we were talking about him only the other day. He chose us, much to the relief of the rescue. He was given up as he chewed through a door, he was bored as his mum and dad were at work every day.

I had Moderna last week, no reaction at all.

Wow, K Cider is still out there!

Used to drink K back in late 80s, early 90s, along with Gaymers Old English. To get drunk quickly mixed cider and lager - a snakebite.

Yup. My old dog had a pack for her lunch when we were out in the hills so she could have regular treats. Otherwise she'd eat rabbit or sheep poo.

Current one does as when I have my lunch at the top she wants hers too! Here she's wearing my old dog's pack.

https://www.reddit.com/media?url=https%3A%2F%2Fi.redd.it%2Fuygt7ppev3n91.jpg

Both got used to a pack without any issue or hassle.

Some US insurance companies are switching everyone to biosimilars as it's cheaper. They've been available in UK/Europe and elsewhere for years.

The patent on Humira expired years ago. We in UK/EU have had biosimilars for some years. Hyrimoz was first approved in 2015. FDA approved it in 2018. But Abbot/Abbvi made some deal against the biosimilar manufacturers to stall it in the US. Mid 2023 FDA and EU approved Hyrimoz citrate-free high concentration formula.

pneumonia

is an infection, not a reaction. And you would need antibiotics/etc. You could have got it from the original Humira at any point. Or any of the immunsuppressent meds.

Which generic are you taking, Hyrimoz, idacio, Amgevita, etc?
Adalimumab is the scientific name of Humira. Hyrimoz is adalimumab-adaz, etc.

terrible bruise at injection site

Relatively common. I sometimes get a bruise because of catching a small blood vessel with the needle.

I want to ask my doctor to stop completely because I’m breaking out all over my face in whiteheads and my skin is super oily.

Seeing your doctor sounds like a plan. They may want you to try something else which may suit you better.

I'd just point out that people tend to post here when they have problems. We rarely get 'hey it was fine and working already' posts.

It also depends on whether you get multiple loading doses, which depends on your condition and doctors. 160mg over a day or two is more likely to trigger something than 40mg every fortnight - maintenance dose. Or if you've taken and failed any other anti-TNFAlpha drugs, like infliximab - Remicade.

Tiredness, (me: brain fog, outright crappiness) after the injection is common so many of us inject in the evening when we don't have anything planned the next day or two. Other folk have little to no side effects.

I've been on Amgevita (some countries it's called Amjevita) for a few years, I think 3+ (in UK/Europe we've had biosimilars for some years). Works just the same, is not buffered with citric acid, so non-sting. No problems.

I really like the spec of the Ultra. I can see a small cluster to replace my current ageing and power hungry workstation.

If she was very recently spayed she'd have a scar on her tummy and collar to stop her licking the wound. She shouldn't get strenuous games, or long walks/etc until 10 to 14 days post-op, maybe she wont want to anyway due to the hips.

All of our collies, (rescues of mostly around age 5 although current was between 1 and 2 years) have liked a settled, calm, routine. Get them used to the local dog walk to get that social interaction, human and dog as far as they are comfortable. And it gives you indications of how to proceed - is she good with other dogs, fearful, snappy with strangers/etc. Settling in time varies enormously. Some have taken barely 2 weeks, and yet brother of my old dog took a good 2 months.

I'd keep walks short for now and see how she gets on. Ours usually get 3x 1mile a day. Current one gets a longer woods or hill walk once or twice a week. But then she's still young (maybe 6yo), in age and heart!

Medication review with your own vet is a very good plan.

With the hips and spay make sure her weight is good, not too much, not too little/etc.

We've found child gates to partition the house into a dog safe place can help, either away from children, noisy visitor, or hard floor to ease clearing up accidents very useful.

They've also loved new places, woods, or a beach, easy access rivers and streams, introduce gradually as she settles.

Usual maintenance dose is 1x 40mg every other week. Sometimes folk need to go to weekly which is occasionally done as 2x 40mg every other week. Rarely 2x 40mg weekly - you aren't the first I've heard of.

I guess you aren't in remission, with adalimumab serum levels low and zero to low antibodies?

Tiredness kind of goes with the territory, all immune-modulators mess with you to some extent. I found the old drugs azathioprine and methotrexate, way worse.

The trick is to find a biologic, or combination with aza/mtx/etc, which works and the side effects aren't too bad. Inducing remission with steroids, prednisone, and then hoping a biologic will maintain it, is another reasonable approach.

That figures.

Like I said: you have high antibody levels (against the humira). Your doc will/should explain what they mean anyway.

How long after your injection did your doc take bloods for the serum/antibody test? I'm guessing it wasn't taken 2 weeks after which would be the proper time for a trough level.

At the time of the test you had lots of serum, but also high antibody levels.

You might be getting allergic to Humira, it's certainly possible and not that uncommon. I guess you've already tried a number of antihistamines.

You haven't said what you are on Humira for?

Have you talked to your prescribing doctors about this, would they be willing to try you on a different biologic?

You could also be allergic to something in your supplements, food, or skin care. And it could be bacterial, like cellulitis for which you'ld need antibiotics.

Still haven't had covid, at least that I'm aware of. I get less seasonal viruses than before I got onto Humira/biosimilar. And haven't had any in the last few years. Which kind of mirrors my experiences before the Bad Times - flu xmas 1999 through to new year then some form of multi-joint arthritis, then Crohn's, and onto Humira 2009. I was on weekly for a few years and had a few viruses but nothing that made me delay an injection more than a day.

Presumably you're on 80mg every fortnight, rather than 40mg weekly? Is it doing the job, on anything else?

Hey OP... This isn't your dog is it?... It was posted 11 months ago by someone else. 2 day old account, karma farming AH.

https://old.reddit.com/r/BorderCollie/comments/12k6fur/goodbye_bentley_i_love_you/ 

We have maritime weather so it could be quite nice for 2 weeks, or rain every single day all day, but often 4 seasons in one day. Have contingency plans.

I don't see waterproof over-trousers.

For bug spray: buy a can of Smidge when you are here, it works well and doesn't melt synthetic clothing. In still, warm and damp conditions the midges will eat you alive so a sense of humour helps keeping chill.

WHW is a largely lowland route. I wouldn't drink from water courses until well into the hills and even then anywhere near the Way is very likely to be contaminated. Apparently there are fill up points that have been put up in recent years.

You've probably seen this already: https://www.westhighlandway.org/

You might want to look at /r/UlcerativeColitis and /r/CrohnsDisease