Met ingang van 1 juli is het meenemen van fietsen in de trein sterk beperkt.
Een van de meest populaire vouwfietsen, de Strida, mag niet meer meegenomen worden in de trein.
Een ingevouwen vouwfiets mag mee binnen de afmetingen van 45 cm breed x 86 cm lang x 80 cm hoog. De Strida is 113 x 51 x 23 cm.
De ligfiets mag ook niet meer mee met de trein. Maar een ligfiets is niet langer (of breder) is dan een gewone fiets. Wat is hier de gedachte achter?
Terwijl de erg brede fatbike en elektrische fiets wel mee mogen.
Dit betekent dat ik
1. niet meer naar mijn werk kan of een nieuwe vouwfiets moet kopen.
2. niet meer op vakantie kan met de fiets en trein.
Ik vind dit buitengewoon stuitend!
Wat zit hierachter? Ben ik de enige die hier zoveel last van heeft?
I just answered another question about this in this thread
https://www.reddit.com/r/MTHFR/comments/1dsw64t/neurological_symptoms_with_homocysteine_195_level/
But there is also a discussion about how safe creatine is. I'm no doctor, I have no idea if it is safe or not.
I have no idea.
[edit] I copied an artikel about it in this thread.
https://pubmed.ncbi.nlm.nih.gov/23869894/
Creatine (Cr) is recommended as a dietary supplement especially for athletes but its therapeutic potential is also discussed. It is assumed that human body uses Cr for the formation of phosphocreatine, which is necessary for muscular work as a source of energy. Production of Cr in a body is closely connected to methionine cycle where guanidinoacetate (GAA) is in a final step methylated from S-adenosylmethionine (SAM). Increased availability of SAM for phosphatidylcholine (PC) and sarcosine synthesis can potentially stimulate endogenous production of betaine a thus methylation of homocysteine (HCy) to form methionine. Our subject who was methylenetetrahydrofolate reductase (MTHFR) 677TT homozygote lowered plasma HCy from 33.3 micromol/l to 17.1 micromol/l following one-month Cr supplementation (5 g/day) opposite to 677CC and CT genotypes whose HCy levels tended to increase (but still in normal ranges). We suppose that Cr supplementation stimulates pathways leading to production of sarcosine which can serve to regenerate tetrahydrofolate (THF) to form 5,10-methylene-THF. This could potentially increase MTHFR enzyme activity which may later result in increased HCy methylation. Cr supplementation significantly effects metabolism of one carbon unit and potentially lower body´s demands for methyl groups. This could be beneficial as in the case of reduced enzyme activity such as MTHFR 677C/T polymorphism.
Creatinine is a wasteproduct of creatine and is excreted by the kidneys.
Mijn strida staat meestal opgevouwen onder zo'n prullebak op het balkon van de sprinter. Weinig plek voor een mens daar.
En helaas zijn mensen wel eens asociaal. Met of zonder vouwfiets.
Geen idee. Ik dacht van wel maar ik let er verder niet zo op. Ik vind de strida echt wel ideaal.
Wel een beetje moeilijk om een rustig tijdstip te kiezen als ik om half 9 voor de klas moet staan.....
Ik heb erg vaak ligfietsen meegenomen in de trein, en op de plek waar 2, en met wat proppen 3 fietsen kunnen, is dat niet anders met ligfietsen. Dus het is me nooit opgevallen dat het meer plek kostte.
Maar inderdaad, het stoeltje maakt de fiets iets breder, daar heb je gelijk in.
Ik wil echt erg graag begrijpen wat je bedoeld. Het stuur is meestal wel wat smaller dan van een conventionele fiets, maar niet altijd. Het stoeltje is iets breder, bedoel je dat?
Welke omvang bedoel je? Mijn ligfiets is niet langer dan een gewone fiets en ook niet breder.
It also remains difficult because everyone reacts differently to this kind of thing. I ate egg for years, but I turned out to be really allergic (IgE reaction) to chicken egg protein, but I react with depression to egg yolk, which contains the choline.
I also react with a kind of 'poisoned' brain to nightshades, and this is more common, but others, with the same problem, are more likely to have intestinal, mucosal or joint problems. So it depends on a lot more which is still unknown.
Anyway, if you would suffer from a faulty BChE, you should also suffer from most nightshades - and from cocaine and some anaesthetics. The latter mainly affects muscles that stop working which can be dangerous in surgery.
Because I have a non-functioning BChE enzyme (pseudocholinesterase deficiency), I cannot tolerate TMG and I cannot tolerate eggs or choline.
But it builds up. BChE also acts as a back-up system when the AChE acetylcholinesterase fail for some reason. And that happens when you eat (among other things) nightshades (peppers, potatoes, tomatoes, aubergines, ashwaghanda, etc.).
So I am quite allergic to nightshades, eggs, choline, TMG, etc, but if I avoid them for a while, I can take it a bit.
So maybe you felt good at first because it helped with your MTHFR gene, but then it built up and you couldn't break it down properly and you suffered from excess acetylcholine.
(edit AChE-I in AChE)
Igene is available in Germany and the Netherlands. But maybe it is better to find a doctor who knows more about it.
IGene via an alternative GP. He shared the results with me, because as a patient you get only very brief information about this.
But there are other agencies conducting gene research. I hear about 23andme a lot, but I have no experience with it.
You should also look at the COMT gene. That has mainly to do with methylation. If it goes too fast or too slow, it greatly affects how you feel, because all kinds of neurotransmitters but especially dopamine, adrenaline and noradrenaline are processed too fast or too slow.
And because you have billions of methylations per second in your body, it has a big impact. There is a lot of literature about it. You can search on COMT but also on undermethylation or overmethylation.
And in my experience, mental health also depends on chemical processes. If that is not going well, you will suffer from depression, anxiety and all kinds of problems.
Especially in combination with the MTHFR gene.
But be very careful with supplements. For instance, due to the BChE enzym not working, I can't handle TMG and Choline. Due to another faulty gene, I can't take glutamine. So it is really very complex.
It's also dependent on at least 1 other gene expression: BChE gene is responsible for processing (acetyl)choline, and if that doesn't work properly you're likely to get a lot of side effects from choline.
For me a very little bit of choline is already excessive.
I live in the Netherlands, but it is the same for many European countries, I have no idea what the copyright rules are in the rest of the world.
But a colleague of mine recently did a copyright course taught from an American university, and I didn't get the impression that the rules were that different.
Not in my country. The copyright applies to the work created by the bought pattern as wel.
Copyright differs by country. The copyright of the country where you bought the pattern is valid, not the country where you use the pattern.
For instance:
//A pattern for crocheting, knitting and the like can also be a copyrighted 'work', if it is sufficiently original. The copyright owner has the sole right to reproduce and/or make public his or her 'work' (i.e. copy it in any form and/or make it accessible to the public in any form, such as selling or exhibiting it). Someone who buys such a pattern, implicitly gets the right to use the pattern in a knitting or embroidery work etc., because that is what it is meant for. The purchase does not imply that the purchaser may exploit the work himself, for example by marketing the products from the pattern. That is considered a copyright infringement, and the rights holder has the right to take action against that.
What is allowed is to resell the purchased pattern second-hand or give it away to someone else. But that only applies to the one copy that you have (rightfully) acquired. You may not make copies or derivative works of it and then distribute those, whether or not for payment.//
I think i'd want to live in The Vangavaye-ve, the island group from The Hands of The Emperor.
You are right that emotions and feelings can change. A genetic defect cannot change. Those also cause anxiety disorders and depression.
Anxiety and depression are not just a wrong way of thinking or an unpleasant experience to get over. That can undoubtedly also be a cause, but certainly not the determining one in many people.
Not all anxiety can be treated. Sometimes it really is too complex to deal with. A large proportion of anxiety disorders are physical. Medicine still knows very little about it.
And believe me, it really kills. If someone is completely desperate, day after day, with no way out, wouldn't you call that unbearable suffering?
Such a person would not be entitled to euthanasia, but someone with a physical condition whose cause is known would be?
I am curious as to the source of the belief that all 'mental' disorders can be treated.
I hope someone answers these questions, because I also really want to know!
Questions about dopamine reuptake
MTHFR