The joke is about how big media franchises nowadays seem to be creatively helmed by progressives who don't care about honoring the source material, antagonize the fans, and produce subpar schlock. A lot of them are women, and a lot of the fans they antagonize are male.
It's saying that men should get revenge by infiltrating the Lifetime Network (which makes a lot of romance movies targeted towards women) and getting them to make movies that pander to men.
Imo the problem is more that often the people they bring in just aren't good writers. Arcane added a bunch of queer material and was better for it, the Harley Quinn show is fire so far. Companies just need to hire writers instead of PR specialists.