In any activity that's harder than a patrol zone, you will get nuked by void damage. Whether it's the aeon maul from hydras, void emersion from the warlord meatball, a minotaur torch hammer, or an ogre eye blast, you will absolutely get nuked. Even if you have 100 resilience with void resist and concussive dampener and a more than adequate power level you will get nuked. Regardless of the burns or mods, you will get destroyed. Wyverns? Better dodge the spread from those chickens because they will blow you up instantly. I have never experienced any of the insane damage from other sources. Only void. And it's insanely annoying.