Tried magic mushrooms and LSD a few times. I was piiiiissed when I learned that my antidepressants counteract their effects.
Jfc is this why I’m resistant to shrooms????
The psilocybin in mushrooms metabolizes into psylocin. This compound acts on serotonin receptors in the brain. So if you're on an SSRI or SSNI, they kind of beat the shrooms to the punch.
They definitely can still work though.