I feel that there is a major issue with using a low-width (1 or 1.5 unit) key for Space that I haven't seen discussed anywhere. It is an issue with most of the more advanced mech ergo boards on the market in my opinion. It can be visualized by looking at the wear patterns of spacebars (see the thread image) on much-used keyboards - the area where the key is usually pressed on standard keyboards is much wider than 1 unit. Therefore, in my opinion, the ideal width of a spacbar / space key is 2 units, extending inwards from the thumb's natural resting position with the other fingers on the home keys. This should at least be true for the thumb that enters Space but probably also for the other side if planning to use the main secondary thumb key as a modifier, like Shift.

Spacebar wear pattern example 

Why? Well, when you hit a key with your index finger on the center column (e. g. 'h' or 'n' on QWERTY) followed by space on a keyboard with a 1 unit space key, you will have to return your hand to the home position before being able to hit space, which will slow you down. If you're using QWERTY, frequent words that end in 'n', like 'in', 'on' etc. will become annoying once you switch to such a thumb cluster board.

To illustrate (for people using their right thumb only for space): On a standard keyboard, type the word 'am', paying close attention to the location where you touch the spacebar with your thumb after the 'm'. Then do the same thing typing the word 'an'. Compare the exact spot where your thumb presses space this time. For me, there is a definite shift in thumb press position.

Unless you are going to / have switched to a layout that de-emphasizes the center columns, this might become a PITA. I own a Keyboardio Model 100, for example, and what I am describing is definitely an issue for me. I personally feel that one wide thumb key and one additional key outwards (i. e. in the direction of the pinky) from the center for each thumb is the best solution - can't really see myself using more than those thumb two keys on each side while typing.

Of course, the same effect occurs in the other direction when you use keys outwards from the pinky's home column. However, to avoid this issue, you'd have to have an even larger space key that extends pinky-wards, too, and you'd be stuck with only one easily accessible key per thumb so in that regard, I'd prefer having the additional thumb key. With regard to the relatively frequently used center columns, though, a narrow thumb key is a hard sell for me, at least for QWERTY users. I guess it's all a question of preference - if some really wants a lot of thumb keys or uses a center-deemphasized layout, they might be willing to sacrifice the comfort / speed advantage of a wider thumb key to make room for an additional key whereas someone focused mostly on writing text on QWERTY should probably reconsider.

As for alleviating this through layout design, I guess it would be best to put letters in the central column that are A) infrequent and B) rarely appear at the ends of words. The worst choice of layout with a narrow thumb key design seems to be one with punctuation (which is almost always followed directly by space) on the central column as, for example, with the Engram layout.

To be honest, I've never really typed much on such keyboards so this comes from a hypothetical / theoretical perspective. Please do contradict me if my theory is at odds with your own experience.

[Edit:] The issue seems to be more inherent to row-staggered boards as the hand has to move further inward for the index to reach the most distant key on the central column.