do colleges care about region?

I'd be willing to bet that you have as many volunteering opportunities as anywhere else.

Internships for high school students aren't common. Most students accepted to top schools did not have an internship in high school.

Often overlooked in this subreddit: a typical teen job, in a business. Typical as in grocery, fast food, retail, etc. Hard work, responsibility, real world experience, context for future learning, and a place to start your resume when you apply to internships during college.

Admissions assessed based upon what opportunities exist

That said, I doubt any admissions office will but into a statement that there aren't opportunities in the five-county SE PA area.

they really don't. but when you apply they have people sometimes look into where your from and the opportunities you have available in your area. as well, most high schools have to send the courses they offer and nearby opportunities to admissions offices, and to FAFSA as well, im not very sure tho, dont mark my words on that